Eosinophilic granuloma is characterized by lesions that arise predominantly in bones. Treatment for eosinophilic granuloma depends on several factors and usually includes a combination of surgery, chemotherapy, radiation therapy and corticosteroids. However, for some patients, close observation alone may be the appropriate course of action.
Eosinophilic granuloma is the most common and the mildest subtype of a group of diseases known as Langerhans cell histiocytosis—disorders in which there is an overproliferation of Langerhans cells.
Usually found in the skull bones, eosinophilic granuloma can also arise in other bones, such as the vertebrae, ribs, mandibles and bones in the limbs. This disorder can sometimes arise in the lungs, skin and stomach too.
Eosinophilic granuloma most frequently appears as a single lesion, but multiple lesions are also possible.
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