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Giant Aneurysm SCENT Trial Projected to Finish in 2015

Dr. Philip Meyers
Dr. Philip Meyers-

Two years ago, we announced that Dr. Philip Meyers and Dr. Sean Lavine from the Endovascular Center were beginning a new clinical trial for the treatment of brain aneurysms: the multi-center Stryker SCENT trial.

At the time, the study’s principal investigator, Dr. Meyers, reported they had treated the first two patients enrolled here at Columbia University Medical Center/New York Presbyterian Hospital.

Today there are over 100 patients enrolled in the SCENT trial at 25 centers nationwide, as well as in the Netherlands. Researchers are hopeful they will be able to wrap up the study by the end of 2015.

The SCENT trial (short for Safety and Effectiveness of an Intracranial Aneurysm Embolization System for Treating Large or Giant Wide Neck Aneurysms) is looking at a device called The Surpass Flow Diverter.

Surgeons can permanently implant this device inside a blood vessel in the brain where it can divert blood flow away from an aneurysm. Without its blood supply, an aneurysm will essentially deflate.

An aneurysm occurs because of thinning in a blood vessel wall. The pressure of blood flowing through the vessel causes that part of the wall to bulge outward like a balloon. Because of it’s thin walls, an aneurysm is at risk of bursting and causing a brain bleed. Also, if it grows too big, it can put undue pressure on vital brain structures.

Often an aneurysm has a berry-like shape with a distinct neck that can be clipped and closed off surgically. Other types of aneurysms can also be clipped, but the considerations include aneurysm shape and location. Department Chair, Dr. Robert Solomon and Dr. E. Sander Connolly from the Cerebrovascular Center specialize in this treatment arena.

Endovascular surgeons like Dr. Meyers and Dr. Lavine treat aneurysms from inside the blood vessel using a variety of techniques including the use of coils and special glues.

In some cases, an aneurysm is too big or its neck is too wide and irregular to easily fix. Then, treatment using these established methods can fall short. “Large and giant aneurysms often don’t stay well blocked by coils alone,” says Dr. Meyers.

Cerebrovascular surgeons are looking for new treatments for these harder-to-treat cases. Flow diverting devices like Medtronic’s Pipeline and the Surpass system under study in the SCENT trial are a new option at the forefront.

“Flow diversion has a high rate of aneurysm cure,” says Dr. Meyers. This is why he and Dr. Lavine are participating in the SCENT trial here at Columbia. They are hopeful that the Surpass Flow Diverter will prove safe and effective, and that it will allow them save even more lives.

You can learn more about this trial here

Learn more about SCENT Principal Investigator, Dr. Philip Meyers on his bio page here.

Lavine_7705_Edit
Dr. Sean Lavine

Learn more about SCENT Sub-Investigator, Dr. Sean Lavine on his bio page here.

Related: 

patient journey

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