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Dr. Bruce Harnessing the Body’s Immune System to Kill Brain Tumors

Dr. Jeffrey Bruce
Dr. Jeffrey Bruce

Dr. Jeffrey N. Bruce, director of the Bartoli Brain Tumor Research Laboratory at Columbia University Medical Center is one of the senior authors* of a recently published paper on the use of a vaccine on glioblastomas, one of the most deadly of brain tumors.

The paper, Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial, is published in the January 2014 issue of the English journal, Neuro-Oncology.

“Harnessing the body’s immune system to kill brain tumors is a potentially powerful treatment strategy,” says Dr. Bruce. “This paper describes our experience with a novel vaccine that proved to be effective in patients whose glioblastoma had grown back after standard treatment with radiation and chemotherapy. The vaccine was developed by Dr. Andy Parsa, who was one of our former residents at Columbia [2002]. We collaborated with him on this experimental trial and are excited about moving forward with a plan to treat more patients.”

Read more about this research online here or in Neuro Oncol. 2014 Jan;16(2):274-9.

Andrew T. Parsa, MD, PhD, is now Chairman of the Department of Neurological Surgery at Northwestern University’s Feinberg School of Medicine. You can learn more about Dr. Parsa’s many collaborations with Dr. Bruce in our previous posts:

You can learn more about Dr. Jeffrey Bruce on his bio page here.

* Authors include: Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, Butowski NA, Chang SM, Clarke JL, McDermott MW, Prados MD, Sloan AE, Bruce JN, Parsa AT.

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