Dr. Jeffrey Bruce, MD and Dr. Anthony D’Ambrosio, MD of Columbia University Medical Center/NewYork-Presbyterian Hospital recently collaborated with immunology company Agenus in research on a potential new treatment for glioblastoma multiforme. The research was selected for presentation at the American Society of Clinical Oncology‘s annual meeting because of its promise for future treatment of this highly malignant brain tumor
Currently, surgery is the primary treatment for glioblastoma multiforme, but it rarely provides a cure. Chemotherapy and radiation can help, but the outlook for these patients is poor. That is why our neurosurgeons are so invested in researching this disease. And this new research offers exciting possibilities for these patients.
The research focused on a vaccine called Prophage. The vaccine is autologous, meaning it is created from the tumor itself. At the time the tumor is removed surgically, tissue from the tumor itself is used to create a vaccine. This vaccine is then given to the patient to stimulate their immune system to fight the tumor.
Patients who received the vaccine showed longer survival rates overall. In particular, the group of patients with a low expression of a particular protein called PD-L1 in their tumor had great benefits from the vaccine. Their median survival increased from a historical expectation of 14-19 months to 44.7 months.
“I am hopeful that with continued success in the clinic, Prophage has the potential to be a much-needed treatment option for patients with glioblastoma,” explains Dr. Bruce. These results offer hope for future treatment of glioblastoma multiforme, as well as direction for further research into treatments that can continue to improve outcomes for those who receive this unfortunate diagnosis.
Photo credit: anidmi via Dollar Photo Club.
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